RESEARCH ARTICLE
A Review Paper on Biomimetic Calcium Phosphate Coatings
X. Lin1, 2, K. de Groot1, D. Wang1, Q. Hu3, D. Wismeijer1, Y. Liu1, *
Article Information
Identifiers and Pagination:
Year: 2015Volume: 9
Issue: Suppl 1-M4
First Page: 56
Last Page: 64
Publisher ID: TOBEJ-9-56
DOI: 10.2174/1874120701509010056
Article History:
Received Date: 30/4/2014Revision Received Date: 31/5/2014
Acceptance Date: 30/8/2014
Electronic publication date: 27/2/2015
Collection year: 2015
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Biomimetic calcium phosphate coatings have been developed for bone regeneration and repair because of their biocompatibility, osteoconductivity, and easy preparation. They can be rendered osteoinductive by incorporating an osteogenic agent, such as bone morphogenetic protein 2 (BMP-2), into the crystalline lattice work in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation. Therefore, biomimetic calcium phosphate coatings are considered to be a promising delivery vehicle for osteogenic agents. In this review, we present an overview of biomimetic calcium phosphate coatings including their preparation techniques, physico-chemical properties, potential as drug carrier, and their pre-clinical application both in ectopic and orthotopic animal models. We briefly review some features of hydroxyapatite coatings and their clinical applications to gain insight into the clinical applications of biomimetic calcium phosphate coatings in the near future.