RESEARCH ARTICLE


A Review Paper on Biomimetic Calcium Phosphate Coatings



X. Lin1, 2, K. de Groot1, D. Wang1, Q. Hu3, D. Wismeijer1, Y. Liu1, *
1 Department of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands
2 Department of Orthodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China
3 Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China


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Creative Commons License
© Lin et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to the author at the Department of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands; Tel: +31020 5980626; Fax: +31020 5980333; E-mail: y.liu@acta.nl


Abstract

Biomimetic calcium phosphate coatings have been developed for bone regeneration and repair because of their biocompatibility, osteoconductivity, and easy preparation. They can be rendered osteoinductive by incorporating an osteogenic agent, such as bone morphogenetic protein 2 (BMP-2), into the crystalline lattice work in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation. Therefore, biomimetic calcium phosphate coatings are considered to be a promising delivery vehicle for osteogenic agents. In this review, we present an overview of biomimetic calcium phosphate coatings including their preparation techniques, physico-chemical properties, potential as drug carrier, and their pre-clinical application both in ectopic and orthotopic animal models. We briefly review some features of hydroxyapatite coatings and their clinical applications to gain insight into the clinical applications of biomimetic calcium phosphate coatings in the near future.

Keywords: Animal model, biomimetic, calcium phosphate coating, clinical application, drug delivery, hydroxyapatite, osseoconduction, osseoinduction, pre-clinical study.