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The Open Biomedical Engineering Journal is an Open Access online journal which publishes original research articles, reviews/mini-reviews, letters and guest edited single topic issues in all areas of biomedical engineering. The journal focuses on the original high-quality multidisciplinary research in the field of biosystems, including biomedical modeling; cell and tissue engineering for repair medicine; biomeasurements, biosignal processing and biosensing systems; artificial and bioartificial organs; biomaterials; biomechanics and rehabilitation, medical information systems and neuronal networks; brain-computer interfaces, communication technologies in medicine, medical imaging including brain functional magnetic resonance imaging (fMRI), genome analysis, medical physics, bioinformatics, biophotonics and optical tomography.

The Open Biomedical Engineering Journal, a peer reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality articles rapidly and freely available to researchers worldwide.

Editor's Choice

Influence of Geometric Changes in the Thoracic Aorta due to Arterial Switch Operations on the Wall Shear Stress Distribution

Tomohiro Fukui, Hiroaki Asama, Manabu Kimura, Toshiyuki Itoi, Koji Morinishi


The transposition of the great arteries (TGA) is one of the most severe congenital heart diseases. The arterial switch operation (ASO) is the preferred procedure to treat TGA. Although numerous reports have shown good results after ASOs, some patients suffer from circulatory system problems following the procedure. One reason for problems post-ASO is the local changes in the curvature and torsion of the thoracic aorta.


The influence of these geometric changes on the blood flow field needs to be investigated in detail to consider possible cardiovascular problems after an ASO.


In this study, we conduct blood flow simulations in the thoracic aorta post-ASO, evaluate geometric changes in the aorta due to the ASO in terms of curvature and torsion, and consider the effect of geometric changes on blood flow in the aorta.


It was found that a large curvature near the aortic root causes an increase in the maximal wall shear stress value in the middle systole. Moreover, a large torsion results in a circumferential change in the maximal wall shear stress region. It was also found that the maximal wall shear stress in the post-ASO models is significantly higher than that in the normal models. This indicates that the aortic aneurysm initiation risk for a post-ASO artery may be higher than that of a normal artery.


To reduce the risk of initiating an aneurism, it is suggested that the curvature near the aortic root should be decreased during the ASO.

February 16, 2017

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