RESEARCH ARTICLE

Modeling of Drug Delivery by A Pump Driven Micro-Needle Array System

The Open Biomedical Engineering Journal 30 Mar 2016 RESEARCH ARTICLE DOI: 10.2174/1874120701610010019

Abstract

Background:

Micro-needles were proposed as one of the alternatives to deliver drugs painlessly passing through stratum corneum in recent years. In this work, a mathematical model is presented to characterize the in fusion flow of a hollow micro-needle array driven by a micro-pump.

Methods:

By assuming the injection of each micro-needle undergoes a spherical expansion and diffusion, the model is able to calculate the time-varying expansion radius, and the diffusion boundary, provided that the material properties and the micro-needle system parameters are known.

Results and Conclusion:

The calculation results show that the expansion caused by the infusion of micro-needles stops and the flow rate drops to zero in a short time. However, the diffusion boundary is much bigger than the expansion and the infusion continues if the surrounding material is absorptive. The experimental results of jet infusion through a single needle in silicon rubber and polyacrylamide gel agree with the calculation results qualitatively.

Keywords: Drug delivery system, fluid infusion, micro-needle, infusion flow.
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