Research on the Influence of Anti-fatigue Effect and Movement Ability of Blueberry Polysaccharides on Aged Mice

Bai Bo, * Open Modal Authors Info & Affiliations
The Open Biomedical Engineering Journal 19 Oct 2015 RESEARCH ARTICLE DOI: 10.2174/1874120701509010314


The article introduces functions as well as extraction and purification of polysaccharides, and the effect of blueberry polysaccharides (BPs) on movement endurance, anti-fatigue capacity and related physiological indexes in aged mice induced by D-galactose is going to be investigated. The method of water extract-alcohol precipitation is used in the experiment to extract polysaccharides from blueberries, and in-vitro oxidation resistance and bacteriostasis of polysaccharides are studied after preliminary purification so as to provide a reference for the production and application of blueberry polysaccharides. Mice are randomly divided into a normal control group, an aged model group, a BP low-dose group, a BP medium-dose group, and a BP high-dose group. After the administration of BPs for 20 consecutive days, the exhaustive swimming time and fatigue indexes are determined. The results show that BPs could prolong the exhaustive swimming time, decrease the content of BUN, BLA and MDA, and obviously increase the activity of HG, MG, SOD and LDH. To conclude, BPs have good anti-fatigue effect. This study may provide theoretical evidence for the development of anti-fatigue drugs from BPs.

Keywords: Anti-fatigue effect, blueberry polysaccharides, exhaustive swimming, extraction, purification D-galactose.
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